CPX-351 versus 7+3 cytarabine and daunorubicin chemotherapy in older adults with newly diagnosed high-risk or secondary acute myeloid leukaemia: 5-year results of a randomised, open-label, multicentre, phase 3 trial

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Financial Disclosure Statement

JEL has received consulting fees from AbbVie, BerGenBio/DAVA Oncology, Celgene/Bristol Myers Squibb, Daiichi Sankyo, ElevateBio Management, Millennium Pharma/Takeda, and Novartis. GLU has received consulting fees from AbbVie, Agios, GlaxoSmithKline, Jazz Pharmaceuticals, and Novartis, and received honoraria from Astellas Pharma. TLL has received institutional research funding from AbbVie, Aptevo, Astellas Pharma, Bio-Path Holdings, Celgene, Celyad, Genentech/Roche, Gilead Sciences, Incyte, Jazz Pharmaceuticals, Mateon Therapeutics, Ono Pharmaceutical, Pfizer, Prescient Therapeutics, Seattle Genetics, Tolero Pharmaceuticals, and Trovagene. EKR has served as a consultant for Celgene, Incyte, Novartis, and Pfizer; served on speakers bureaus for Ariad Pharmaceuticals, Celgene, Incyte, and Novartis; received research funding from Astellas Pharma, Bristol Myers Squibb, Novartis, NS Pharma, and Pfizer; and received travel support from Celgene and Novartis. RKS has served as a consultant for Sunesis Pharmaceuticals; received honoraria from Sunesis Pharmaceuticals; received research funding from Agios, Astellas Pharma, Bayer AG, Incyte, Jazz Pharmaceuticals, Ono Pharmaceuticals, and Sunesis Pharmaceuticals; and received travel support from Sunesis Pharmaceuticals. SAS has served as a consultant for AbbVie, ArcherDx, Astellas Pharma, Genentech, Incyte, Jazz Pharmaceuticals, Kite Pharma, Kura Oncology, and Novartis; and received research funding from Sunesis Pharmaceuticals. JEK participated in advisory boards for Amgen, Magellan, and Pfizer, and has served on the editorial board for UpToDate. GJS has received research funding from AbbVie, Agios, Actinium, Amgen, Ariad Pharmaceuticals, Astellas Pharma, Bristol Myers Squibb, Constellation, Cyclacel, Daiichi Sankyo, Deciphera, Delta-Fly, Forma, Fujifilm, Gamida, Genentech/Roche, Geron, Incyte, Jazz Pharmaceuticals, Karyopharm, Kite Pharma, Mateon, MedImmune, Novartis, Onconova, Pfizer, Regimmune, Samus, Sangamo, Tolero, and Trovagene; received consulting fees from Agios, Amgen, AstraZeneca, Incyte, Novartis, and Ono Pharma; served on speakers bureaus for Agios, Amgen, Celgene, Gilead Sciences, Incyte, Sanofi, and Stemline; provided expert testimony for Kaiser Permanente; and holds stock ownership and options in Amgen, Bristol Myers Squibb, Johnson & Johnson, and Pfizer. MJW has received research funding from Amgen, Leadiant, Merck, and Shire; participated in advisory committees for Daiichi Sankyo; and holds stock ownership in Reata Pharmaceuticals. DHR holds stock ownership in AbbVie and patents and royalties with the University of Rochester. SF is an employee of and holds stock ownership and options in Jazz Pharmaceuticals. JEC has received consulting fees from Astellas Pharma, Daiichi Sankyo, Jazz Pharmaceuticals, Novartis, and Pfizer; and research funding (to his institution) from Arog, Astellas Pharma, Daiichi Sankyo, Jazz Pharmaceuticals, Novartis, and Pfizer. All other authors declare no competing interests.

Detailed information on funding amounts received by the authors of this publication is available at http://www.cms.gov/openpayments.

INDICATION

VYXEOS^® (daunorubicin and cytarabine) liposome for injection 44 mg/100 mg is indicated for the treatment of newly-diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC) in adults and pediatric patients 1 year and older.